abstract：BACKGROUND:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion mutation in the coding region of a novel gene. The mechanism of HD is unknown. Most data suggest that polyglutamine-mediated aggregation associated with expression of mutant huntingtin protein (mhtt) contri...

journal_title：BMC neuroscience

authors： Trushina E,Rana S,McMurray CT,Hua DH

更新日期：2009-07-08 00:00:00

abstract：BACKGROUND:Reuptake of synaptic norepinephrine (NE) via the antidepressant-sensitive NE transporter (NET) supports efficient noradrenergic signaling and presynaptic NE homeostasis. Limited, and somewhat contradictory, information currently describes the axonal transport and localization of NET in neurons. RESULTS:We e...

journal_title：BMC neuroscience

authors： Matthies HJ,Han Q,Shields A,Wright J,Moore JL,Winder DG,Galli A,Blakely RD

更新日期：2009-06-23 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons (MN) in the brain stem and spinal cord. Intracellular disruptions of cytosolic and mitochondrial calcium have been associated with selective MN degeneration, but the underlying mecha...

journal_title：BMC neuroscience

authors： Jaiswal MK,Zech WD,Goos M,Leutbecher C,Ferri A,Zippelius A,Carrì MT,Nau R,Keller BU

更新日期：2009-06-22 00:00:00

abstract：BACKGROUND:Gap junction proteins, connexins, are expressed in most endocrine and exocrine glands in the body and are at least in some glands crucial for the hormonal secretion. To what extent connexins are expressed in neurons releasing hormones or neuropeptides from or within the central nervous system is, however, un...

journal_title：BMC neuroscience

authors： Westberg L,Sawa E,Wang AY,Gunaydin LA,Ribeiro AC,Pfaff DW

更新日期：2009-04-30 00:00:00

abstract：BACKGROUND:The mismatch negativity (MMN) is an early component of event-related potentials/fields, which can be observed in response to violations of regularities in sound sequences. The MMN can be elicited by simple feature (e.g. pitch) deviations in standard oddball paradigms as well as by violations of more complex ...

journal_title：BMC neuroscience

authors： Herholz SC,Lappe C,Pantev C

更新日期：2009-04-30 00:00:00

abstract：BACKGROUND:Impaired speech perception is one of the major sequelae of aging. In addition to peripheral hearing loss, central deficits of auditory processing are supposed to contribute to the deterioration of speech perception in older individuals. To test the hypothesis that auditory temporal processing is compromised ...

journal_title：BMC neuroscience

authors： Sörös P,Teismann IK,Manemann E,Lütkenhöner B

更新日期：2009-04-07 00:00:00

abstract：BACKGROUND:In rodents, dietary Na+ deprivation reduces gustatory responses of primary taste fibers and central taste neurons to lingual Na+ stimulation. However, in the rat taste bud cells Na+ deprivation increases the number of amiloride sensitive epithelial Na+ channels (ENaC), which are considered as the "receptor" ...

journal_title：BMC neuroscience

authors： Huang T,Stähler F

更新日期：2009-03-12 00:00:00

abstract：BACKGROUND:Lateralized processing of speech is a well studied phenomenon in humans. Both anatomical and neurophysiological studies support the view that nonhuman primates and other animal species also reveal hemispheric differences in areas involved in sound processing. In recent years, an increasing number of studies ...

journal_title：BMC neuroscience

authors： Fischer J,Teufel C,Drolet M,Patzelt A,Rübsamen R,von Cramon DY,Schubotz RI

更新日期：2009-02-24 00:00:00

abstract：BACKGROUND:Subjective tinnitus is characterized by an auditory phantom perception in the absence of any physical sound source. Consequently, in a quiet environment, tinnitus patients differ from control participants because they constantly perceive a sound whereas controls do not. We hypothesized that this difference i...

journal_title：BMC neuroscience

authors： Schlee W,Hartmann T,Langguth B,Weisz N

更新日期：2009-02-19 00:00:00

abstract：BACKGROUND:Magnetoencephalography (MEG) has become an increasingly popular technique for non-invasively characterizing neuromagnetic field changes in the brain at a high temporal resolution. To examine the reliability of the MEG signal, we compared magnetic and electrophysiological responses to complex natural stimuli ...

journal_title：BMC neuroscience

authors： Zhu Z,Zumer JM,Lowenthal ME,Padberg J,Recanzone GH,Krubitzer LA,Nagarajan SS,Disbrow EA

更新日期：2009-01-15 00:00:00

abstract：INTRODUCTION:NAP (Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln, single amino acid letter code, NAPVSIPQ), an eight amino acid neuroprotective peptide derived from activity-dependent neuroprotective protein (ADNP), exhibits some structural similarity to activity-dependent neurotropic factor-9 (ADNF-9; Ser-Alal-Leu-Leu-Arg-Ser-Ile-Pr...

journal_title：BMC neuroscience

authors： Gozes I,Divinski I,Piltzer I

更新日期：2008-12-10 00:00:00

abstract：:Many studies have highlighted the pathological involvement of iron accumulation and iron-related oxidative stress (OS) in Alzheimer's disease (AD). Iron was further demonstrated to modulate expression of the Alzheimer's amyloid precursor holo-protein (APP) by a mechanism similar to that of regulation of ferritin-L and...

journal_title：BMC neuroscience

authors： Avramovich-Tirosh Y,Amit T,Bar-Am O,Weinreb O,Youdim MB

更新日期：2008-12-03 00:00:00

abstract：BACKGROUND:We have recorded responses from single neurons in murine visual cortex to determine the effectiveness of the input from the two murine cone photoreceptor mechanisms and whether there is any unique selectivity for cone inputs at this higher region of the visual system that would support the possibility of col...

journal_title：BMC neuroscience

authors： Ekesten B,Gouras P

更新日期：2008-11-14 00:00:00

abstract：BACKGROUND:Multi-sensory integration is necessary for organisms to discriminate different environmental stimuli and thus determine behavior. Caenorhabditis elegans has 12 pairs of amphid sensory neurons, which are involved in generating behaviors such as thermotaxis toward cultivation temperature, and chemotaxis toward...

journal_title：BMC neuroscience

authors： Adachi R,Osada H,Shingai R

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:A delay in surgical nerve repair results in impaired nerve function in humans, but mechanisms behind the weakened nerve regeneration are not known. Activating transcription factor 3 (ATF3) increases the intrinsic growth state of injured neurons early after injury, but the role of long-term changes and their ...

journal_title：BMC neuroscience

authors： Saito H,Dahlin LB

更新日期：2008-09-18 00:00:00

abstract：BACKGROUND:Several studies have shown that Stroop interference is stronger in children than in adults. However, in a standard Stroop paradigm, stimulus interference and response interference are confounded. The purpose of the present study was to determine whether interference at the stimulus level and the response lev...

journal_title：BMC neuroscience

authors： Jongen EM,Jonkman LM

更新日期：2008-09-05 00:00:00

abstract：BACKGROUND:Ample evidence suggests a substantial contribution of cellular and molecular changes in the spinal cord to the induction and persistence of chronic neuropathic pain conditions. While for a long time, proteases were mainly considered as protein degrading enzymes, they are now receiving growing interest as sig...

journal_title：BMC neuroscience

authors： Leichsenring A,Bäcker I,Wendt W,Andriske M,Schmitz B,Stichel CC,Lübbert H

更新日期：2008-08-12 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of nigrostriatal dopaminergic systems. Free radicals induced by oxidative stress are involved in the mechanisms of cell death in PD. This study clarifies the neuroprotective effects of edaravone (MCI-186, 3-methyl-1-phenyl-...

journal_title：BMC neuroscience

authors： Yuan WJ,Yasuhara T,Shingo T,Muraoka K,Agari T,Kameda M,Uozumi T,Tajiri N,Morimoto T,Jing M,Baba T,Wang F,Leung H,Matsui T,Miyoshi Y,Date I

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Human neural stem cells (hNSC) have the potential to provide novel cell-based therapies for neurodegenerative conditions such as multiple sclerosis and Parkinson's disease. In order to realise this goal, protocols need to be developed that allow for large quantities of hNSC to be cultured efficiently. As suc...

journal_title：BMC neuroscience

authors： Hall PE,Lathia JD,Caldwell MA,Ffrench-Constant C

更新日期：2008-07-23 00:00:00

abstract：BACKGROUND:During development the switch from a depolarizing to a hyperpolarizing action of GABA is a consequence of a decrease of the Na+-K+-2Cl- co-transporter (NKCC1, Cl--uptake) and increase of the K+-Cl- co-transporter (KCC2, Cl--extrusion) expression. However albino visual cortex neurons don't show a correspondin...

journal_title：BMC neuroscience

authors： Diykov D,Turchinovich A,Zoidl G,Hoffmann KP

更新日期：2008-06-30 00:00:00

abstract：BACKGROUND:It has been reported that various types of axonal injury of hypothalamo-neurohypophyseal tract can result in degeneration of the magnocellular neurons (MCNs) in hypothalamus and development of central diabetes insipidus (CDI). However, the mechanism of the degeneration and death of MCNs after hypophysectomy ...

journal_title：BMC neuroscience

authors： Wang Y,Zhao C,Wang Z,Wang C,Feng W,Huang L,Zhang J,Qi S

更新日期：2008-06-25 00:00:00

abstract：BACKGROUND:Tone languages such as Thai and Mandarin Chinese use differences in fundamental frequency (F0, pitch) to distinguish lexical meaning. Previous behavioral studies have shown that native speakers of a non-tone language have difficulty discriminating among tone contrasts and are sensitive to different F0 dimens...

journal_title：BMC neuroscience

authors： Kaan E,Barkley CM,Bao M,Wayland R

更新日期：2008-06-23 00:00:00

abstract：BACKGROUND:Previous studies in the rat have shown that the spatial organisation of the receptive fields of nociceptive withdrawal reflex (NWR) system are functionally adapted through experience dependent mechanisms, termed somatosensory imprinting, during postnatal development. Here we wanted to clarify 1) if mice exhi...

journal_title：BMC neuroscience

authors： Thelin J,Schouenborg J

更新日期：2008-05-21 00:00:00

abstract：BACKGROUND:The polyglutamine expansion in huntingtin (Htt) protein is a cause of Huntington's disease (HD). Htt is an essential gene as deletion of the mouse Htt gene homolog (Hdh) is embryonic lethal in mice. Therefore, in addition to elucidating the mechanisms responsible for polyQ-mediated pathology, it is also impo...

journal_title：BMC neuroscience

authors： Zhang H,Das S,Li QZ,Dragatsis I,Repa J,Zeitlin S,Hajnóczky G,Bezprozvanny I

更新日期：2008-04-15 00:00:00

abstract：BACKGROUND:The zitter (zi/zi) rat, a loss-of-function mutant of the glycosylated transmembrane protein attractin (atrn), exhibits widespread age-dependent spongiform degeneration, hypomyelination, and abnormal metabolism of reactive oxygen species (ROS) in the brain. To date, the mechanisms underlying these phenotypes ...

journal_title：BMC neuroscience

authors： Sakakibara S,Nakadate K,Ookawara S,Ueda S

更新日期：2008-04-05 00:00:00

abstract：BACKGROUND:Huntington's disease (HD) is a neurodegenerative disorder predominantly affecting the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat encoding an expanded polyglutamine tract in the N-terminus of the huntingtin protein, closely model HD. We have previously shown that enviro...

journal_title：BMC neuroscience

authors： van Dellen A,Cordery PM,Spires TL,Blakemore C,Hannan AJ

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Previous studies found that rats subjected to carrageenan injection develop hyperalgesia, and despite complete recovery in several days, they continue to have an enhanced hyperalgesic response to a new noxious challenge for more than 28d. The study's aim was to identify candidate genes that have a role in th...

journal_title：BMC neuroscience

authors： Yukhananov R,Kissin I

更新日期：2008-03-13 00:00:00

abstract：BACKGROUND:One of the most promising options for treatment of stroke using adult stem cells are human umbilical cord blood (HUCB) cells that were already approved for therapeutic efficacy in vivo. However, complexity of animal models has thus far limited the understanding of beneficial cellular mechanisms. To address t...

journal_title：BMC neuroscience

authors： Hau S,Reich DM,Scholz M,Naumann W,Emmrich F,Kamprad M,Boltze J

更新日期：2008-02-29 00:00:00

abstract：BACKGROUND:Peripherin, a type III neuronal intermediate filament, is widely expressed in neurons of the peripheral nervous system and in selected central nervous system hindbrain areas with projections towards peripheral structures, such as cranial nerves and spinal cord neurons. Peripherin appears to play a role in ne...

journal_title：BMC neuroscience

authors： Eriksson KS,Zhang S,Lin L,Larivière RC,Julien JP,Mignot E

更新日期：2008-02-24 00:00:00

abstract：BACKGROUND:Neurogenesis continues to occur throughout life but dramatically decreases with increasing age. This decrease is mostly related to a decline in proliferative activity as a result of an impoverishment of the microenvironment of the aged brain, including a reduction in trophic factors and increased inflammatio...

journal_title：BMC neuroscience

authors： Bachstetter AD,Pabon MM,Cole MJ,Hudson CE,Sanberg PR,Willing AE,Bickford PC,Gemma C

更新日期：2008-02-14 00:00:00

abstract：BACKGROUND:Amyloid precursor protein (APP) is enzymatically cleaved by gamma-secretase to form two peptide products, either Abeta40 or the more neurotoxic Abeta42. The Abeta42/40 ratio is increased in many cases of familial Alzheimer's disease (FAD). The transmembrane domain (TM) of APP contains the known dimerization ...

journal_title：BMC neuroscience

authors： Gorman PM,Kim S,Guo M,Melnyk RA,McLaurin J,Fraser PE,Bowie JU,Chakrabartty A

更新日期：2008-01-30 00:00:00

abstract：BACKGROUND:Chlamydophila (Chlamydia) pneumoniae is an intracellular bacterium that has been identified within cells in areas of neuropathology found in Alzheimer disease (AD), including endothelia, glia, and neurons. Depending on the cell type of the host, infection by C. pneumoniae has been shown to influence apoptoti...

journal_title：BMC neuroscience

authors： Appelt DM,Roupas MR,Way DS,Bell MG,Albert EV,Hammond CJ,Balin BJ

更新日期：2008-01-24 00:00:00

abstract：BACKGROUND:Glutamate gated postsynaptic receptors in the central nervous system (CNS) are essential for environmentally stimulated behaviours including learning and memory in both invertebrates and vertebrates. Though their genetics, biochemistry, physiology, and role in behaviour have been intensely studied in vitro a...

journal_title：BMC neuroscience

authors： Ryan TJ,Emes RD,Grant SG,Komiyama NH

更新日期：2008-01-15 00:00:00

abstract：BACKGROUND:After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In ...

journal_title：BMC neuroscience

authors： Beaud ML,Schmidlin E,Wannier T,Freund P,Bloch J,Mir A,Schwab ME,Rouiller EM

更新日期：2008-01-14 00:00:00

abstract：BACKGROUND:Mitochondrial DNA (mtDNA) mutations, which are present in all mitochondria-containing cells, paradoxically cause tissue-specific disease. For example, Leber's hereditary optic neuropathy (LHON) results from one of three point mutations mtDNA coding for complex I components, but is only manifested in retinal ...

journal_title：BMC neuroscience

authors： Hoegger MJ,Lieven CJ,Levin LA

更新日期：2008-01-08 00:00:00

abstract：BACKGROUND:Granulocyte-macrophage colony stimulating factor (GM-CSF) is a hematopoietic growth factor involved in the generation of granulocytes, macrophages, and dendritic cells from hematopoietic progenitor cells. We have recently demonstrated that GM-CSF has anti-apoptotic functions on neurons, and is neuroprotectiv...

journal_title：BMC neuroscience

authors： Krüger C,Laage R,Pitzer C,Schäbitz WR,Schneider A

更新日期：2007-10-22 00:00:00

abstract：BACKGROUND:Agmatine is an endogenous polyamine formed by the decarboxylation of L-arginine. We investigated the protective effects of agmatine against hypoxia-induced apoptosis of immortalized rat retinal ganglion cells (RGC-5). RGC-5 cells were cultured in a closed hypoxic chamber (5% O2) with or without agmatine. Cel...

journal_title：BMC neuroscience

authors： Hong S,Lee JE,Kim CY,Seong GJ

更新日期：2007-10-02 00:00:00

abstract：:Numerous molecular factors orchestrate the development of the peripheral taste system. The unique anatomy/function of the taste system makes this system ideal for understanding the mechanisms by which these factors function; yet the taste system is underutilized for this role. This review focuses on some of the many f...

journal_title：BMC neuroscience

authors： Krimm RF

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Evoked potentials have been proposed to result from phase-locking of electroencephalographic (EEG) activities within specific frequency bands. However, the respective contribution of phasic activity and phase resetting of ongoing EEG oscillation remains largely debated. We here applied the EEGlab procedure i...

journal_title：BMC neuroscience

authors： Cheron G,Cebolla AM,De Saedeleer C,Bengoetxea A,Leurs F,Leroy A,Dan B

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:The effects induced by administering the anticonvulsant lamotrigine, the preferential inhibitor of neuronal nitric oxide synthase 7-nitroindazole and the precursor of NO synthesis L-arginine, alone or in combination, on an experimental model of partial complex seizures (maximal dentate gyrus activation) were...

journal_title：BMC neuroscience

authors： Sardo P,Ferraro G

更新日期：2007-07-03 00:00:00